Greater celandine

Greater celandine as it relates to DILI in Health report: Genetics of Antibiotics-Induced Liver Injury

Greater celandine (Chelidonium majus) and Drug-Induced Liver Injury (DILI)

Greater celandine is a plant that has been traditionally used in herbal medicine for various purposes, including liver disorders. However, it is important to note that greater celandine has been associated with cases of Drug-Induced Liver Injury (DILI) in some individuals.

Studies have shown that the active compounds in greater celandine, such as alkaloids and flavonoids, can have hepatotoxic effects in certain individuals. These compounds can cause liver damage and inflammation, leading to DILI. Symptoms of DILI may include jaundice, fatigue, nausea, and abdominal pain.

It is important to exercise caution when using greater celandine or products containing this herb, especially in high doses or for prolonged periods. Individuals with pre-existing liver conditions or those taking medications known to affect the liver should consult with a healthcare provider before using greater celandine.

In conclusion, while greater celandine has been traditionally used for liver health, it is essential to be aware of the potential risks of DILI associated with this herb and to use it judiciously under the guidance of a healthcare professional.

Supplements for DILI

Here are some dietary supplements related to the content in this report. Click the shopping cart to purchase the supplement from our partners.

  1. Green tea extract

    Contains catechins which may increase oxidative stress and liver cell damage when combined with hepatotoxic antibiotics.

  2. Greater celandine

    Alkaloids like chelidonine may further impair liver function when the organ is under stress from antibiotics.

  3. Chaparral

    Nordamnacanthal is a quinone that could synergistically increase antibiotic liver toxicity through mitochondrial dysfunction.

  4. Germander

    Diterpenoids may amplify antibiotic liver injury by disrupting bile salt export and causing cholestasis.

  5. Mistletoe

    Contains toxic lectins which could worsen immunological reactions or alter detox pathways of antibiotic metabolites.

  6. Skullcap

    Flavonoids may inhibit pathways involved in hepatic metabolism and clearance of antibiotics from the liver.

  7. Valerian

    Isovaltrate and other constituents thought to directly damage cell membranes, potentially worsening antibiotic hepatocellular toxicity.

  8. Kava kava

    Kavalactones like desmethoxyyangonin may inhibit CYP450 liver enzymes important for antibiotic clearance.

  9. St. John's wort

    Hyperforin alters PXR nuclear receptors and could decrease bile acid transport, contributing to antibiotic cholestasis.

  10. Ginseng

    Ginsenosides may inhibit P-glycoprotein transporters important for antibiotic efflux from hepatocytes, allowing accumulation of toxic levels.

  11. Aloe vera

    Anthraquinone glycosides possibly damage cell membranes and worsen antibiotic-mediated liver cell necrosis.

  12. Ashwagandha

    Withanolides thought to cause oxidative stress which synergizes with redox-cycling antibiotic metabolites.

  13. Andrographis

    Diterpene lactones may reduce bile acid secretion and flow, contributing to cholestatic injury.

  14. Noni juice

    Anthraquinones could impair mitochondrial function and increase antibiotic hepatotoxicity.

  15. Peppermint oil

    Menthol interferes with CYP450s and UGTs involved in antibiotic metabolism and clearance.

  16. Kratom

    Mitragynine and 7-hydroxymitragynine are metabolized in liver and could enhance antibiotic toxicity.

  17. Ephedra

    Ephedrine alkaloids may deplete glutathione and reduce the liver's defense against antibiotic oxidative damage.

It is essential to consult your healthcare provider before starting any of these supplements. They can have side effects, and some may interact with medications or other supplements you're already taking.
Disclaimer